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1

An Efficient Synthesis of N-Methyl Amino Acids by Way of Intermediate 5-Oxazolidinones.

Luigi Aurelio, John S. Box, Robert T. C. Brownlee, Andrew B. Hughes, Marianne M. Sleebs

Journal:

Year:

2003

File:

PDF, 257 KB

2003

2

An Efficient Synthesis of N -Methyl Amino Acids by Way of Intermediate 5-Oxazolidinones

Aurelio, Luigi, Box, John S., Brownlee, Robert T. C., Hughes, Andrew B., Sleebs, Marianne M.

Journal:

Journal of Organic Chemistry

Year:

2003

Language:

english

File:

PDF, 308 KB

english, 2003

3

ChemInform Abstract: The Facile Production of N-Methyl Amino Acids via Oxazolidinones.

Luigi Aurelio, Robert T. C. Brownlee, Andrew B. Hughes, Brad E. Sleebs

Journal:

Year:

2000

File:

PDF, 31 KB

2000

4

Total Synthesis of Bassiatin (I) and Its Stereoisomers: Novel Divergent Behavior of Substrates in Mitsunobu Cyclizations.

Andrew B. Hughes, Marianne M. Sleebs

Journal:

Year:

2005

File:

PDF, 9 KB

2005

5

ChemInform Abstract: Studies of 2-Substituted 1,3-Oxazolidin-5-ones and 1,3-Oxazinan-6-ones as Precursors for the Synthesis of N-Alkyl-β-amino Acids.

Andrew B. Hughes, Brad E. Sleebs

Journal:

Year:

2009

File:

PDF, 46 KB

2009

6

ChemInform Abstract: Recent Advances in Stereoselective Synthesis and Application of β-Amino Acids

Brad E. Sleebs, T. T. Van Nguyen, Andrew B. Hughes

Journal:

Year:

2010

File:

PDF, 17 KB

2010

7

Effective Methods for the Synthesis of N-Methyl β-Amino Acids from All Twenty Common α-Amino Acids Using 1,3-Oxazolidin-5-ones and 1,3-Oxazinan-6-ones

Andrew B. Hughes, Brad E. Sleebs

Journal:

Helvetica Chimica Acta

Year:

2006

Language:

english

File:

PDF, 278 KB

english, 2006

8

M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe

Benny J. Evison, Mile Pastuovic, Rebecca A. Bilardi, Robert A. Forrest, Paul P. Pumuye, Brad E. Sleebs, Keith G. Watson, Don R. Phillips, Suzanne M. Cutts

Journal:

Biochemical Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.28 MB

english, 2011

9

Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors

Brad E. Sleebs, George Nikolakopoulos, Ian P. Street, Hendrik Falk, Jonathan B. Baell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 335 KB

english, 2011

10

Corrigendum to “Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors” [Bioorg. Med. Chem. Lett. 21 (2011) 5992–5994]

Brad E. Sleebs, George Nikolakopoulos, Ian P. Street, Hendrik Falk, Jonathan B. Baell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 225 KB

english, 2012

11

Diastereoselective synthesis of highly functionalized β2,2,3-substituted amino acids from 4-substituted-1,3-oxazinan-6-ones

Nghi H. Nguyen, Brad E. Sleebs, Jonathan M. White, Andrew B. Hughes

Journal:

Year:

2012

Language:

english

File:

PDF, 607 KB

english, 2012

12

Total Synthesis of the Antifungal Depsipeptide Petriellin A

Sleebs, Marianne M., Scanlon, Denis, Karas, John, Maharani, Rani, Hughes, Andrew B.

Journal:

Journal of Organic Chemistry

Year:

2011

Language:

english

File:

PDF, 1.41 MB

english, 2011

13

10.1071/ch99082

Aurelio, Luigi, Brownlee, Robert T. C., Hughes, Andrew B., Sleebs, Brad E.

Journal:

Australian Journal of Chemistry

Year:

2000

Language:

english

File:

PDF, 189 KB

english, 2000

14

Studies of 2-Substituted 1,3-Oxazolidin-5-ones and 1,3-Oxazinan-6-ones as Precursors for the Synthesis of N-Alkyl-β-Amino Acids

Hughes, Andrew B., Sleebs, Brad E.

Journal:

Synthetic Communications

Year:

2008

Language:

english

File:

PDF, 318 KB

english, 2008

15

New Anthracenedione Derivatives with Improved Biological Activity by Virtue of Stable Drug−DNA Adduct Formation

Mansour, Oula C., Evison, Benny J., Sleebs, Brad E., Watson, Keith G., Nudelman, Abraham, Rephaeli, Ada, Buck, Damian P., Collins, J. Grant, Bilardi, Rebecca A., Phillips, Don R., Cutts, Suzanne M.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.24 MB

english, 2010

16

Recent Advances in Stereoselective Synthesis and Application of β-Amino Acids

Sleebs, Brad, Van Nguyen, T. T., Hughes, Andrew

Journal:

Organic Preparations and Procedures International

Year:

2009

Language:

english

File:

PDF, 3.82 MB

english, 2009

17

P.4.d.001 BNC210 is a novel, fast acting compound with potent anxiolytic activity and no side effects

S. O'Connor, E. Andriambeloson, B. Huyard, S. Wagner, B. Sleebs, C. Bui, G. Kremmidiotis, I. Street, B. Flynn

Journal:

European Neuropsychopharmacology

Year:

2008

Language:

english

File:

PDF, 56 KB

english, 2008

18

ChemInform Abstract: Diastereoselective Synthesis of Highly Functionalized β 2,2,3 -Substituted Amino Acids from 4-Substituted-1,3-oxazinan-6-ones.

Nguyen, Nghi H., Sleebs, Brad E., White, Jonathan M., Hughes, Andrew B.

Journal:

Year:

2012

File:

PDF, 53 KB

2012

19

Corrigendum to “Diastereoselective synthesis of highly functionalized β2,2,3-substituted amino acids from 4-substituted-1,3-oxazinan-6-ones” [Tetrahedron 68 (2012) 4745–4756]

Nghi H. Nguyen, Brad E. Sleebs, Jonathan M. White, Andrew B. Hughes

Journal:

Year:

2012

Language:

english

File:

PDF, 72 KB

english, 2012

20

Structure-guided design of a selective BCL-XL inhibitor

Lessene, Guillaume, Czabotar, Peter E, Sleebs, Brad E, Zobel, Kerry, Lowes, Kym N, Adams, Jerry M, Baell, Jonathan B, Colman, Peter M, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Gibbons, P

Journal:

Nature Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.54 MB

english, 2013

21

Diastereoselective synthesis of cyclic β2,3-amino acids utilizing 4-substituted-1,3-oxazinan-6-ones

Sleebs, Brad E., Nguyen, Nghi H., Hughes, Andrew B.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.40 MB

english, 2013

22

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X L

Sleebs, Brad E., Kersten, Wilhemus J. A., Kulasegaram, Sanji, Nikolakopoulos, George, Hatzis, Effie, Moss, Rebecca M., Parisot, John P., Yang, Hong, Czabotar, Peter E., Fairlie, W. Douglas, Lee, Erinn

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.94 MB

english, 2013

23

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Sleebs, Brad E., Czabotar, Peter E., Fairbrother, Wayne J., Fairlie, W. Douglas, Flygare, John A., Huang, David C. S., Kersten, Wilhelmus J. A., Koehler, Michael F. T., Lessene, Guillaume, Lowes, Kym,

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.81 MB

english, 2011

24

Diastereoselective Synthesis of α-Methyl and α-Hydroxy-β-Amino Acids via 4-Substituted-1,3-Oxazinan-6-ones

Sleebs, Brad E., Hughes, Andrew B.

Journal:

Journal of Organic Chemistry

Year:

2007

Language:

english

File:

PDF, 232 KB

english, 2007

25

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

Koehler, Michael F. T., Bergeron, Philippe, Choo, Edna F., Lau, Kevin, Ndubaku, Chudi, Dudley, Danette, Gibbons, Paul, Sleebs, Brad E., Rye, Carl S., Nikolakopoulos, George, Bui, Chinh, Kulasegaram, S

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.12 MB

english, 2014

26

Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P. falciparum and P. vivax

Sleebs, Brad E., Gazdik, Michelle, O’Neill, Matthew T., Rajasekaran, Pravin, Lopaticki, Sash, Lackovic, Kurt, Lowes, Kym, Smith, Brian J., Cowman, Alan F., Boddey, Justin A.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 708 KB

english, 2014

27

Total Synthesis of Bassiatin and Its Stereoisomers: Novel Divergent Behavior of Substrates in Mitsunobu Cyclizations

Hughes, Andrew B., Sleebs, Marianne M.

Journal:

Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 247 KB

english, 2005

28

Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors

Sleebs, Brad E., Levit, Alla, Street, Ian P., Falk, Hendrik, Hammonds, Tim, Wong, Ai Ching, Charles, Mark D., Olson, Michael F., Baell, Jonathan B.

Journal:

Year:

2011

Language:

english

File:

PDF, 156 KB

english, 2011

29

Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors

Sleebs, Brad E., Ganame, Danny, Levit, Alla, Street, Ian P., Gregg, Alison, Falk, Hendrik, Baell, Jonathan B.

Journal:

Year:

2011

Language:

english

File:

PDF, 114 KB

english, 2011

30

Role of Plasmepsin V in Export of Diverse Protein Families from the Plasmodium falciparum Exportome

Boddey, Justin A., Carvalho, Teresa G., Hodder, Anthony N., Sargeant, Tobias J., Sleebs, Brad E., Marapana, Danushka, Lopaticki, Sash, Nebl, Thomas, Cowman, Alan F.

Journal:

Year:

2013

Language:

english

File:

PDF, 18.15 MB

english, 2013

31

ChemInform Abstract: Stereoselective Synthesis and Application of β-Amino Ketones

Nguyen, Nghi H., Hughes, Andrew B., Sleebs, Brad E.

Journal:

Year:

2014

File:

PDF, 17 KB

2014

32

The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V

Gazdik, Michelle, O'Neill, Matthew T., Lopaticki, Sash, Lowes, Kym N., Smith, Brian J., Cowman, Alan F., Boddey, Justin A., Sleebs, Brad E.

Journal:

Year:

2015

Language:

english

File:

PDF, 523 KB

english, 2015

33

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

Lee, E. F., Czabotar, P. E., Yang, H., Sleebs, B. E., Lessene, G., Colman, P. M., Smith, B. J., Fairlie, W. D.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 3.05 MB

english, 2009

34

Inhibitors of Leishmania GDP-Mannose Pyrophosphorylase Identified by High-Throughput Screening of Small-Molecule Chemical Library

Lackovic, K., Parisot, J. P., Sleebs, N., Baell, J. B., Debien, L., Watson, K. G., Curtis, J. M., Handman, E., Street, I. P., Kedzierski, L.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2010

Language:

english

File:

PDF, 1.42 MB

english, 2010

35

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Sleebs, Brad E., Lopaticki, Sash, Marapana, Danushka S., O'Neill, Matthew T., Rajasekaran, Pravin, Gazdik, Michelle, Günther, Svenja, Whitehead, Lachlan W., Lowes, Kym N., Barfod, Lea, Hviid, Lars, Sh

Journal:

Year:

2014

Language:

english

File:

PDF, 1.91 MB

english, 2014

36

Synthesis of N-Cbz-Substituted β3-Amino Ketones Utilizing 4-Substituted 1,3-Oxazinan-6-ones

Sleebs, Brad, Nguyen, Nghi, Hughes, Andrew

Journal:

Year:

2013

Language:

english

File:

PDF, 211 KB

english, 2013

37

A Mild Multistep Conversion of N-Protected α-Amino Acids into N-Protected β3-Amino Acids Utilizing the Nef Reaction

Sleebs, Brad, Nguyen, Nghi, Hughes, Andrew

Journal:

Year:

2013

Language:

english

File:

PDF, 201 KB

english, 2013

38

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

Hodder, Anthony N, Sleebs, Brad E, Czabotar, Peter E, Gazdik, Michelle, Xu, Yibin, O'Neill, Matthew T, Lopaticki, Sash, Nebl, Thomas, Triglia, Tony, Smith, Brian J, Lowes, Kym, Boddey, Justin A, Cowma

Journal:

Nature Structural and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 2.06 MB

english, 2015

39

α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells

Checco, James W., Lee, Erinna F., Evangelista, Marco, Sleebs, Nerida J., Rogers, Kelly, Pettikiriarachchi, Anne, Kershaw, Nadia J., Eddinger, Geoffrey A., Belair, David G., Wilson, Julia L., Eller, Ch

Journal:

Journal of the American Chemical Society

Year:

2015

Language:

english

File:

PDF, 4.49 MB

english, 2015

40

De Novo Synthesis of a Potent LIMK1 Inhibitor

Sleebs, Brad, Street, Ian, Bu, Xian, Baell, Jonathan

Journal:

Year:

2010

Language:

english

File:

PDF, 123 KB

english, 2010

41

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum

Wilson, Danny W, Goodman, Christopher D, Sleebs, Brad E, Weiss, Greta E, de Jong, Nienke WM, Angrisano, Fiona, Langer, Christine, Baum, Jake, Crabb, Brendan S, Gilson, Paul R, McFadden, Geoffrey I, Be

Journal:

Year:

2015

Language:

english

File:

PDF, 2.89 MB

english, 2015

42

Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

Gazdik, Michelle, Jarman, Kate E., O’Neill, Matthew T., Hodder, Anthony N., Lowes, Kym N., Jousset Sabroux, Helene, Cowman, Alan F., Boddey, Justin A., Sleebs, Brad E.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.79 MB

english, 2016

43

Reversible and formaldehyde-mediated covalent binding of WEHI-150 to DNA

Konda, Shyam K, Kelso, Celine, Pumuye, Paul, Medan, Jelena, Sleebs, Brad E., Cutts, Suzanne M, Phillips, Don R, Collins, John Grant

Journal:

Organic & Biomolecular Chemistry

Year:

2016

Language:

english

File:

PDF, 1.85 MB

english, 2016

44

Synthesis of amino heterocycle aspartyl protease inhibitors

Chambers, Rachel K., Khan, Tanweer A., Olsen, David B., Sleebs, Brad E.

Journal:

Organic & Biomolecular Chemistry

Year:

2016

Language:

english

File:

PDF, 1.42 MB

english, 2016

45

Mitoxantrone, More than Just Another Topoisomerase II Poison

Evison, Benny J., Sleebs, Brad E., Watson, Keith G., Phillips, Don R., Cutts, Suzanne M.

Journal:

Medicinal Research Reviews

Year:

2016

Language:

english

File:

PDF, 1.05 MB

english, 2016

46

ChemInform Abstract: A Mild Multistep Conversion of N-Protected α-Amino Acids into N-Protected β 3 -Amino Acids Utilizing the Nef Reaction.

Sleebs, Brad E., Nguyen, Nghi H., Hughes, Andrew B.

Journal:

Year:

2013

File:

PDF, 36 KB

2013

47

ChemInform Abstract: Synthesis of N-Cbz-Substituted β 3 -Amino Ketones Utilizing 4-Substituted 1,3-Oxazinan-6-ones.

Sleebs, Brad E., Nguyen, Nghi H., Hughes, Andrew B.

Journal:

Year:

2013

File:

PDF, 33 KB

2013

48

Isolation and structural analysis of the covalent adduct formed between a bis-amino mitoxantrone analogue and DNA: a pathway to major–minor groove cross-linked adducts

Konda, Shyam K., Kelso, Celine, Medan, Jelena, Sleebs, Brad E., Phillips, Don R., Cutts, Suzanne M., Collins, J. Grant

Journal:

Organic & Biomolecular Chemistry

Year:

2016

Language:

english

File:

PDF, 1.93 MB

english, 2016

49

Analysis of Ca 2+ mediated signalling regulating Toxoplasma infectivity reveals complex relationships between key molecules

Stewart, Rebecca J., Whitehead, Lachlan, Nijagal, Brunda, Sleebs, Brad E., Lessene, Guillaume, McConville, Malcolm J, Rogers, Kelly L., Tonkin, Christopher J.

Journal:

Cellular Microbiology

Year:

2016

Language:

english

File:

PDF, 4.58 MB

english, 2016

50

Synthesis of New β-Amino Acids via 5-Oxazolidinones and the Arndt–Eistert Procedure

Hughes, Andrew B., Sleebs, Brad E.

Journal:

Australian Journal of Chemistry

Year:

2005

Language:

english

File:

PDF, 231 KB

english, 2005

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